Joseph Collins

Joseph Collins, Ph.D.

Research Assistant Professor

Department: Pharmacotherapy & Translational Research
Business Phone: (386) 747-1316
Business Email: jcoll86@ufl.edu

About Joseph Collins

Joseph Collins, Ph.D., is a Research Assistant Professor in the Department of Pharmacotherapy and Translational Research at the University of Florida College of Pharmacy. Dr. Collins received his Ph.D. in Plant Molecular and Cellular Biology in 2018 from the University of Florida. Before becoming UF faculty in the fall of 2023, Dr. Collins worked as a post-doctoral researcher investigating the underlying cause of variable expression of the pharmacogenes in the UF department of pharmacotherapy and translational research.

Dr. Collins’s research interests are related to the regulation of gene expression and how genetic and epigenetic variation contributes to differential gene expression. He uses bioinformatics and functional genomics to identify putative targets and then validates them through an array of molecular biology approaches. His current research focuses on the identification of enhancers that control key pharmacogenes and the identification of novel variants to explain observed differences in gene expression between populations.

Teaching Profile

Courses Taught
2019
BSC2005 Biological Sciences
2014-2018
BSC2010L Integrated Principles of Biology Laboratory 1
2016
BSC2010 Integrated Principles of Biology 1
2014
PCB7922 Journal Colloquy in Plant Molecular and Cellular Biology

Publications

2023
A Comprehensive Evaluation of the Effects of RNA-Editing Proteins ADAR and ADARB1 on the Expression of the Drug-Metabolizing Enzymes in HepaRG Cells.
Drug metabolism and disposition: the biological fate of chemicals. 51(11):1508-1514 [DOI] 10.1124/dmd.123.001396. [PMID] 37532539.
2023
A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples.
Frontiers in pharmacology. 14 [DOI] 10.3389/fphar.2023.1186540. [PMID] 37576811.
2022
Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver.
Frontiers in pharmacology. 13 [DOI] 10.3389/fphar.2022.943538. [PMID] 36059981.
2022
Regulation of CYP3A4 and CYP3A5 by a lncRNA: a potential underlying mechanism explaining the association between CYP3A4*1G and CYP3A metabolism.
Pharmacogenetics and genomics. 32(1):16-23 [DOI] 10.1097/FPC.0000000000000447. [PMID] 34320606.
2022
Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5.
Clinical and translational science. 15(11):2720-2731 [DOI] 10.1111/cts.13398. [PMID] 36045613.
2022
Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.
Drug metabolism and disposition: the biological fate of chemicals. 50(1):43-48 [DOI] 10.1124/dmd.121.000649. [PMID] 34697082.
2021
Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1.
Drug metabolism and personalized therapy. 36(3):205-214 [DOI] 10.1515/dmpt-2020-0160. [PMID] 33823094.
2021
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization.
Journal of pharmacological and toxicological methods. 112 [DOI] 10.1016/j.vascn.2021.107117. [PMID] 34474151.
2021
ESR1 ChIP-Seq Identifies Distinct Ligand-Free ESR1 Genomic Binding Sites in Human Hepatocytes and Liver Tissue.
International journal of molecular sciences. 22(3) [DOI] 10.3390/ijms22031461. [PMID] 33540646.
2021
Protein complex formation in methionine chain-elongation and leucine biosynthesis.
Scientific reports. 11(1) [DOI] 10.1038/s41598-021-82790-4. [PMID] 33568694.
2021
SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(2):347-356 [DOI] 10.1002/jbmr.4185. [PMID] 32967053.
2020
Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.
Pharmacogenetics and genomics. 30(5):107-116 [DOI] 10.1097/FPC.0000000000000402. [PMID] 32301865.

Contact Details

Phones:
Business:
(386) 747-1316
Emails:
Business:
jcoll86@ufl.edu
Addresses:
Business Mailing:
PO Box 100486
GAINESVILLE FL 32610
Business Street:
1345 CENTER DRIVE MSB ROOM PG-07
GAINESVILLE FL 32610