Yuanyuan Jiao, Ph.D., leverages her extensive clinical expertise to develop translational Quantitative and Systems Pharmacology (QSP) models which can rationally optimize innovative antibiotic combination dosing strategies. Founded on receptor binding data, she recently developed a mechanistic double-and triple-β-lactam combination model to combat multidrug-resistant bacterial ‘superbugs’. These QSP models play a critical role in our awarded NIH R01, with Dr. Jiao serving as a lead modeler on this NIH project. Moreover, Dr. Jiao has performed meta-analyses of randomized clinical trials on the efficacy and safety of double β-lactam combination therapies which compared favorably to β-lactam plus aminoglycoside combinations. Finally, she has developed the first population pharmacokinetic model to elucidate the complex metabolism in cystic fibrosis patients compared to that in healthy volunteers using plasma and urine data for a quinolone antibiotic.
In addition to this antimicrobial research, Dr. Jiao is playing a critical role as study coordinator in the planning and performance of two ongoing FDA-sponsored clinical trials at UF. She has gained extensive experience in the clinical protocol and ICF development, IRB & RIHSC processes, in-depth study design, execution and administration, as well as communication with the sponsor (FDA) and multiple international collaborators.
Both within Dr. Bulitta’s antimicrobial NIH & FDA program, as well as the FDA program by Drs. Hochhaus and Bulitta, Dr. Jiao is playing a critical role and has gained substantial experience in preparation, submission and budget planning of 3 NIH-R01s and 3 FDA grants; four of these large, international, collaborative research grants have been funded and two are under review. Further, Dr. Jiao was Co-Investigator on two collaborations with pharmaceutical industry; and she served as teaching assistant for course “Translational Clinical Pharmacology”.
Dr Jiao’s doctoral thesis was titled ‘Investigation on a PEGylated liposome of 8-chloro-adenosine lipophilic derivative: synthesis, formulation, pharmacokinetics and in vitro activity.’ Dr. Jiao has co-mentored 3 Pharmacy students on hospital rotations. She is a member of ASCPT and the International Society of Pharmacometrics.
- Infectious diseases
- Inhaled drugs
- Translational and clinical pharmacology