Yinzhi Lang

Yinzhi Lang, Ph.D.

Research Assistant Professor

Department: Pharmacotherapy & Translational Research
Business Email: y.lang@ufl.edu

About Yinzhi Lang

Yinzhi Lang, PhD, is a Research Assistant Professor in the Department of Pharmacotherapy and Translational Research at the UF College of Pharmacy. Dr. Lang’s research focus on developing novel assays and elucidating the mechanism of drug action and resistance via LC-MS and QSP modeling approach.

Dr. Lang completed her PhD program in 2016 from Ocean University of China. For her doctoral research, she developed advanced biochemical and bioanalytical methods for extracting and analyzing complex biological macromolecules (glycans, proteoglycans, glycoproteins and glycolipids) from various tissues of plants, animals and humans. Between 2016 and 2018, Dr. Lang worked as a senior Scientist in Shanghai Greenvalley Pharmaceutical Co.Ltd. She played an integrated role on developing instrumental analysis methods (LC-MS, CE-MS & GC-MS) for QC and ADME study of an innovative anti-Alzheimer agent GV-971 (Phase III, NCT04520412).

In 2018, Dr. Lang joined the College of Pharmacy at UF as a Postdoc and has received systematic training in antimicrobial pharmacology, pharmacokinetics and pharmacodynamics from Dr. Bulitta and his collaborators. She has created a series of UPLC-MRM-MS/MS assays to quantify the target site penetration of antibacterial in Gram-negative bacteria, and accumulation of antiviral drugs in mammalian cells. Moreover, she employed LC-MS/MS based proteomics, metabolomics and lipidomics to characterize microbial biomolecules. In 2021, Dr. Lang was appointed as a Research Assistant Professor in the college. She is now significantly contributing to the development of Quantitative and Systems Pharmacology (QSP) models with Dr. Bulitta, which can integrate these mechanistic data with pathogen killing, resistance, tolerance and persistence to rationally optimize anti-infective therapy. Dr. Lang is leading several funded anti-infection projects to create novel insights to combat serious infections.

Related Links:

Board Certifications

  • National Computer Rank Examination (NCRE) (China)
    Visual C++ (Rank II) Certificate
  • National Computer Rank Examination (NCRE) (China)
    Internet technology (Rank III) Certificate

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-6857-4516

Areas of Interest
  • Bioanalysis
  • Infectious diseases
  • Pharmacokinetics/pharmacodynamics
  • Quantitative and Systems Pharmacology modeling
  • Translational and clinical pharmacology

Publications

2022
Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model.
Antibiotics (Basel, Switzerland). 11(1) [DOI] 10.3390/antibiotics11010101. [PMID] 35052977.
2022
Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity.
Antimicrobial agents and chemotherapy. 66(9) [DOI] 10.1128/aac.00527-22. [PMID] 35924913.
2022
Simulated Intravenous versus Inhaled Tobramycin with or without Intravenous Ceftazidime Evaluated against Hypermutable Pseudomonas aeruginosa via a Dynamic Biofilm Model and Mechanism-Based Modeling.
Antimicrobial agents and chemotherapy. 66(3) [DOI] 10.1128/aac.02203-21. [PMID] 35041509.
2022
Why Molnupiravir Fails in Hospitalized Patients
mBio. [DOI] 10.1128/mbio.02916-22.
2021
Combating Multidrug-Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling.
Clinical pharmacology and therapeutics. 109(4):1000-1020 [DOI] 10.1002/cpt.2205. [PMID] 33576025.
2021
Comparison of Different Labeling Techniques for the LC-MS Profiling of Human Milk Oligosaccharides.
Frontiers in chemistry. 9 [DOI] 10.3389/fchem.2021.691299. [PMID] 34589467.
2021
Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy. 65(9) [DOI] 10.1128/AAC.00692-21. [PMID] 34152820.
2020
First Penicillin-Binding Protein Occupancy Patterns for 15 β-Lactams and β-Lactamase Inhibitors in Mycobacterium abscessus.
Antimicrobial agents and chemotherapy. 65(1) [DOI] 10.1128/AAC.01956-20. [PMID] 33106266.
2020
Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.
mBio. 11(1) [DOI] 10.1128/mBio.03189-19. [PMID] 32047131.
2018
Glycosaminoglycanomic profiling of human milk in different stages of lactation by liquid chromatography-tandem mass spectrometry.
Food chemistry. 258:231-236 [DOI] 10.1016/j.foodchem.2018.03.076. [PMID] 29655727.
2018
Separation and Structural Sequence Analysis of Sialylated HMOs via Tandem Mass Spectrometry
Chemical Journal of Chinese Universities. 39(4):645-652 [DOI] 10.7503/cjcu20170593.
2016
In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa.
Molecules (Basel, Switzerland). 21(5) [DOI] 10.3390/molecules21050625. [PMID] 27187337.
2016
Isolation, Purification and Disaccharide Composition Analysis of Chondroitin Sulfate C from IRA Rabbit Lung
Chinese Journal of New Drugs. 25(10):1165-1169
2016
Isolation, purification and structural identification of glycosaminoglycans from porcine lung
Chinese Journal of Pharmaceutical Analysis. 36(4):587-593 [DOI] 10.16155/j.0254-1793.2016.04.05.
2016
Low anticoagulant heparin oligosaccharides as inhibitors of BACE-1, the Alzheimer’s β-secretase.
Carbohydrate polymers. 151:51-59 [DOI] 10.1016/j.carbpol.2016.05.050. [PMID] 27474542.
2015
Extraction, Isolation, Structural Characterization and Anti-Tumor Properties of an Apigalacturonan-Rich Polysaccharide from the Sea Grass Zostera caespitosa Miki.
Marine drugs. 13(6):3710-31 [DOI] 10.3390/md13063710. [PMID] 26110894.
2015
Isolation and Structural Identification of Neutral Human Milk Oligosaccharides
Chemical Journal of Chinese Universities. 36(6):1087-1093 [DOI] 10.7503/cjcu20150118.
2014
Applications of mass spectrometry to structural analysis of marine oligosaccharides.
Marine drugs. 12(7):4005-30 [DOI] 10.3390/md12074005. [PMID] 24983643.
2014
Isolation, purification and fine structure comparison analysis of glycosaminoglycans from three fish gills
Chinese Journal of Marine Drugs. 33(5):1-8 [DOI] 10.13400/j.cnki.cjmd.2014.05.001.
2014
Isolation, purification and physiochemical characteristics comparison study of polysaccharides between wild and low salinity cultured green seaweeds Chaetomorphalinum
Chinese Journal of Marine Drugs. 33(5):31-36 [DOI] 10.13400/j.cnki.cjmd.2014.05.005.
2014
Modification of reduction method about uronic acids in acidic polysaccharides
Chinese Journal of Marine Drugs. 33(4):1-7 [DOI] 10.13400/j.cnki.cjmd.2014.04.001.
2012
Analysis of structural heterogeneity of fucoidan from Hizikia fusiforme by ES-CID-MS/MS.
Carbohydrate polymers. 90(1):602-7 [DOI] 10.1016/j.carbpol.2012.05.084. [PMID] 24751082.

Grants

Sep 2022 ACTIVE
Advancing In Vitro and (patho) Physiology-Based Pharmacokinetics Models to Understand and Predict Pulmonary Absorption and Tissue Retention of Inhaled Drugs
Role: Co-Investigator
Funding: US FOOD AND DRUG ADMN
Jul 2022 ACTIVE
Development of a PO-administered beta-lactam-tarocin combination agent to treat methicillin susceptible and methicillin resistant staphylococci.
Role: Co-Investigator
Funding: PROKARYOTICS via NATL INST OF HLTH NIAID
Mar 2022 ACTIVE
Determination of tobramycin concentrations in plasma and tracheal aspirate of pediatric patients using latest LC-MS/MS
Role: Principal Investigator
Funding: CHILDRENS HOSP PHILADELPHIA via NATL INST OF HLTH NHLBI

Education

Ph.D.
2011-2016 · Ocean University of China
B.S.
2007-2011 · Yantai University

Contact Details

Emails:
Business:
y.lang@ufl.edu
Addresses:
Business Mailing:
6550 SANGER RD OFC 145
ORLANDO FL 32827
Business Street:
6550 SANGER RD
ORLANDO FL 32827