Vivek M Shastri, Ph.D.
Research Assistant Professor
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-6236
Business Email:
vivekshastri@ufl.edu
About Vivek M Shastri
Having obtained his Ph.D. training in cellular and molecular biology, Vivek Shastri joined Dr. Jatinder Lamba’s group in the PTR department at the UF College of Pharmacy. This allowed him to apply his skillset to translational research. One of his interests within the Lamba group is identification, characterization, and validation of pharmacogenomic markers to predict response to therapy in acute myeloid leukemia (AML) patients. He is also leading projects to develop and evaluate novel agents targeting CD33 isoforms to benefit AML patients not responding to currently available immunotherapy options. Another area of focus is understanding the role of senescence in promoting resistance and relapse in AML patients.
Publications
2024
Genetic variation in DNA damage response pathway and response to Gemtuzumab Ozogamicin in pediatric AML: a report from the Children’s Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research.
[DOI] 10.1158/1078-0432.CCR-23-2073.
[PMID] 38197878.
2023
Polygenic Pharmacogenomic Markers as Predictors of Toxicity Phenotypes in the Treatment of Acute Lymphoblastic Leukemia: A Single-Center Study.
JCO precision oncology.
7
[DOI] 10.1200/PO.22.00580.
[PMID] 36952646.
2022
A ten-gene DNA-damage response pathway gene expression signature predicts gemtuzumab ozogamicin response in pediatric AML patients treated on COGAAML0531 and AAML03P1 trials.
Leukemia.
36(8):2022-2031
[DOI] 10.1038/s41375-022-01622-0.
[PMID] 35688939.
2021
A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.
Nucleic acids research.
49(15):8699-8713
[DOI] 10.1093/nar/gkab663.
[PMID] 34370039.
2021
Novel CD33 antibodies unravel localization, biology and therapeutic implications of CD33 isoforms.
Future oncology (London, England).
17(3):263-277
[DOI] 10.2217/fon-2020-0746.
[PMID] 33356566.
2016
Cellular defects caused by hypomorphic variants of the Bloom syndrome helicase gene BLM.
Molecular genetics & genomic medicine.
4(1):106-19
[DOI] 10.1002/mgg3.188.
[PMID] 26788541.
Contact Details
Phones:
- Business:
- (352) 273-6236
Emails:
- Business:
- vivekshastri@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100486
GAINESVILLE FL 32610 - Business Street:
-
1345 CENTER DR
GAINESVILLE FL 32611